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Histamine and prostaglandins are involved in inflammatory reactions.

A) True
B) False

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TLRs are


A) phagocyte receptors that detect PAMPs.
B) the coatings of pathogens by complement.
C) molecules that damage cells, resulting in cell lysis.
D) present in intact skin, sebum, tears, etc.
E) nonspecific leukocytes that secrete toxins onto the surface of virally infected cells.

F) B) and E)
G) C) and D)

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First line of defense may be described as


A) the release of prostaglandins and leukotrienes in response to microbes.
B) intact skin, mucous membranes, sebum, tears, and so forth.
C) damage resulting in cell lysis.
D) the coating of a pathogen by complement.
E) nonspecific leukocytes that secrete toxins onto the surface of virally infected cells.

F) C) and D)
G) B) and E)

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B

Some pathogens produce toxins which function as (histamines/prostaglandins/pyrogens)to cause fever.

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pyrogens

Which of the following contributes to protecting the eyes from microbial invasion?


A) tears contain lysozyme and salt.
B) a mucus layer traps and removes microbes.
C) tears mechanically flush particles from the eyes.
D) tears contain lysozyme and salt and mechanically flush particles from the eyes.
E) tears and mucus combine to trap microbes and remove them.

F) B) and D)
G) C) and E)

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Which of the following substances contributes to the edema associated with inflammation?


A) leukotrienes
B) histamine
C) interferon
D) defensin
E) both leukotrienes and histamine

F) C) and D)
G) B) and C)

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Which of the following is NOT an example of a walled-off site of infection that contains a fluid made of dead and dying tissue cells,leukocytes,and pathogens?


A) a boil
B) an abscess
C) a pimple
D) a pustule
E) a tumor

F) B) and E)
G) A) and B)

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Which of the following are phagocytic cells descended from monocytes?


A) alveolar macrophages
B) dendritic cells
C) microglial cells
D) alveolar macrophages and dendritic cells
E) alveolar macrophages and microglial cells

F) A) and E)
G) None of the above

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The phenomenon known as chemotaxis is defined as


A) the squeezing of cells through the lining of capillaries.
B) the release of prostaglandins and leukotrienes in response to microbes.
C) the movement of a cell toward or away from a chemical stimulus.
D) the coating of a pathogen by complement.
E) an increase in allergies and helminth infection.

F) B) and C)
G) A) and D)

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Microbial molecules detected by phagocytes are called


A) TLRs.
B) NODs.
C) PAMPs.
D) leukotrienes.
E) prostaglandins.

F) A) and D)
G) B) and D)

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Which of the following are macrophage functions?


A) phagocytosis of pathogens and debris
B) release of alpha interferon
C) production of NETs
D) phagocytosis of pathogens and production of NETs
E) phagocytosis of pathogens and secretion of alpha interferons and leukotrienes

F) B) and D)
G) A) and B)

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Proteins on the surface of phagocytes called ________ aid in the detection of pathogen molecules.


A) lectins
B) TLRs
C) NOD proteins
D) lectins and C3 protein
E) both TLRs and NOD proteins

F) All of the above
G) B) and E)

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What is phagocytosis? What does it involve?

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Phagocytosis is a process by which a cell can engulf substances and internalize them into the cytoplasm.Cells that are capable of phagocytosis are collectively known as phagocytes and include neutrophils,eosinophils,dendritic cells,and macrophages.Phagocytosis is part of the body's second line of defense,and it is nonspecific.It includes the following steps: Chemotaxis: a cell moves either toward or away from a chemical stimulus. Adherence: the phagocyte attaches to the pathogen,through binding of complementary chemicals on the membranes of the pathogen. Ingestion: after the pseudopodia adhere to the pathogen,the encompassed microbe is internalized as the pseudopodia fuse to form a sac called a phagosome. Digestion: lysosomes with over 30 digestive enzymes attach to the phagosome and break down the microbe.At the end of this process,the remains of the phagosome are known as the residual body. Elimination: the phagocyte rids itself of undigested material by exocytosis,which is the opposite of ingestion.

A type of lymphocyte called a(n) ________ detects cells with abnormal surface proteins and kills them.


A) eosinophil
B) NK cell
C) neutrophil
D) basophil
E) mast cell

F) B) and C)
G) C) and D)

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The absence of necessary receptors is the basis of the defense against microbial invasion known as (natural/innate/species)resistance.

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Protection from infection known as species resistance is a result of


A) the lack of suitable environment in the body.
B) the absence of receptors required for microbial attachment.
C) the presence of phagocytes in the tissues.
D) the salty, acidic condition of normal skin.
E) both the absence of necessary receptors and lack of suitable environment in the body.

F) A) and B)
G) A) and C)

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Alpha and beta interferons


A) help protect virus-infected cells from the effects of the pathogen.
B) protect the cells that secrete them from being invaded by a virus.
C) are produced by infected fibroblasts and macrophages.
D) produce active antiviral proteins (AVPs) that coat the surface of healthy cells and prevent the attachment of pathogenic viruses.
E) produce no adverse effects in the body.

F) B) and D)
G) A) and C)

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   Examine the WBC count and differential data in Table.What type of disease is indicated by this set of data? Examine the WBC count and differential data in Table.What type of disease is indicated by this set of data?

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The overall elevation of WBC i...

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Interferons alpha and beta are effective against viruses.

A) True
B) False

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Which of the following cells increase in number during an infection with parasitic worms?


A) basophils
B) macrophages
C) neutrophils
D) eosinophils
E) lymphocytes

F) B) and C)
G) C) and D)

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